Atherosclerosis is one of the leading causes of death world-wide. The disease affects small diameter blood vessels in various regions of the body. A number of patients with atherosclerosis must undergo surgical bypass procedures to restore the impaired blood flow in the ischemic region. Currently, using a patient’s own blood vessel to replace the diseased segments gives the best result. Unfortunately, autologous blood vessels are not always available due to concomitant disease or reoperation. Clinically available synthetic substitutes have inadequate long-term performance due to low patency rates and increased susceptibility of graft infection often requiring re-interventions.
Interventional techniques can be applied as first line revascularization therapy. However, therapy often fails and a vascular graft has to be implanted. Current materials for small diameter vessel replacement are still poor substitutes to autologous vessels. Smart vascular substitutes are needed to overcome the limitations. The economic potential of competitive grafts is high and the global vascular graft market will increase due to the prevalence of cardiovascular and nephrology disease. Tissue engineered vascular grafts from biodegradable materials are an attractive alternative to synthetic grafts serving as temporary scaffolds until a new blood vessel has been formed by the host.
Thermoplastic polyurethane elastomers (TPU) show great potential as small diameter vascular replacements because of their biocompatibility and degradation properties. Researchers from the TUWien and Medical University have developed TPU polymer vascular grafts that can be used for small diameter vascular applications where current materials perform inferior. In vitro studies and small rodent studies with these grafts have shown excellent patency after 1 year in the host.
The materials have been characterized in-vitro and in-vivo. Long-term preclinical biological safety studies are necessary to assess the clinical potential of the invention. The start-up will initially purchase the requested materials and spinning capacity from manufacturers to get the (pre)clinical trials going and avoid very large capital investments.
Meet the team
Prof. Bruno Podesser
Professor in cardiac surgery. Head of Center for Biomadical Research Medical University Vienna
28+ years of experience in Vascular Intervention including : coronary, peripheral and Neuro-Intervention procedures but also Transcatheter Valves replacement (Aortic, Mitral and Tricuspid) as well as Robotic applications for coronary and peripheral angioplasties. Has held various roles from Sales Director, Vice-President of Business Development to Chief Operating Officer in a number of small and larger companies in the Vascular field. Significant experience in many projects dealing not only with Sales and Marketing but with R&D, Regulatory and Clinical teams. Passionate with the Vascular field and focusing on next technologies to improve current treatment options for better patients care and survival.
Venture Partner at NLC
Christian is a life science professional, with a passion for translating science into innovations and a particular interest in digital solutions and value creation from data assets. He received his PhD in biophysical chemistry from Heidelberg University and was a postdoc at the Max Planck Society and Harvard University. With more than 16 years of cross-functional and general management experience from large global corporates (Elsevier, Merck), management consulting (BCG) and fast-growing startups (ZAGENO), Christian brings valuable expertise, including: digital product management, strategy development as well as business transformation and scaling.