Since
2018
The Netherlands
Diagnostics
TRL 7

Challenge

The long-term sustainability of our health care system will be based on our ability to provide optimal treatment and therapy selection. Blood based medical tests inform a vast array of medical decisions, and the potential for testing to influence patient outcomes has been extensively demonstrated. Blood sampling is performed in many cases by venous blood draws, performed by specialist nurses in hospitals or specialized clinics. There is an unmet need for minimally invasive blood sampling technologies to facilitate Point of Care and Home-
Use testing.

Opportunity

DTwist is applicable in many segments, such as the Emergency Department, GP office, low resource settings and home use. DTwist intends to sell its device to other Dx test manufacturers to address these end-markets. Addressable segments within the lab based diagnostics segments include immunology (6.15B$), Cardiology (1.55 B$) and inflammatory diseases or syndromes (1.65B$), with CAGRs ranging from 7.5% to 9.6%. The global PoC market is 21.4 B$, expected to reach 38.4 B$ by 2023.

Solution

DTwist has developed a non-invasive single step blood sampling and plasma separation device to capture finger stick blood and separate the plasma into a suitable test or preservation buffer. DTwist’s device has been tested in 1700 patients at high risk of Acute Myocardial Infarction in an Emergency Department in the UK, and shown to be reliable, robust and usable by non-expert users, making the device ideally suitable for decentralized blood sampling and testing.

Status

Efficacy has been demonstrated in a 1700 patient AMI trial in UK hospitals using a lateral flow device as a test read-out platform. This has generated interest from other Dx companies to access DTwist’s device. The device is ready for manufacturing and commercialization. DTwist is seeking investment to optimize its device’s design, enable different back-end technologies that suit lab based and PoC testing, upscale manufacturing and develop Proof of Concepts for Molecular Diagnostics applications and longitudinal home-use testing use cases.

Meet the team

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Anton Pruijssers

CEO of DTwist

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Pieter Wijffels

NLC Venture Partner

Prior to joining NLC as a Venture Partner, Pieter spent 15 years at Philips, bringing innovation to life across the globe. He enjoys working in fast paced environments and supporting initiatives that truly improve the lives of people.