Rheumatoid arthritis (RA) is a chronic inflammatory joint disease affecting almost 20 million people worldwide (2017). Early treatment is essential to slow progression of the disease. With a shortage of rheumatologists in many countries, patients have extensive waiting times (>6months) to get the diagnosis and therapy they need to slow disease progression. There are currently no quick, easy triage tools that can objectively show disease severity and stratify patients that need to see a rheumatologist. There is a need for low-cost and non invasive tools to help triage patients and get them on the right therapy sooner.
With the global RA diagnostic devices market growing at 6% CAGR (2019-2023), it is a growing market which will support the $36 billion RA drug market. NIRVYUhas the potential to change the triage and monitoring process of RA entirely and personalise therapy decisions.
Inflamed joints of a patient with RA undergo pathophysiological changes, including hypoxia, synovial angiogenesis and an increase in leukocyte and protein concentration, altering the optical properties compared to healthy joints. Researchers from Birmingham University have developed a device which shines near-infrared light through the patient’s hand and measures the light at the tissue boundary to show the optical changes in inflamed joints. The device can be used to triage patients and additionally monitor disease severity to help therapy decisions. The IR imager is quick, objective, non-invasive and does not need trained technicians.
A prototype of the device has been developed and evaluated in bench-top testing and the clinical setting. NIRVYU will create more devices to implement in a clinical setting to further validate the proof of concept.
Meet the team
Prof Hamid Dehghani
Venture Partner at NLC
Experienced MedTech executive with ample experience in fund-raising and creating and growing MedTech companies for complex Class II and III medical devices (Sapiens Steering Brain Stimulation, acquired by Medtronic in 2014, GTX medical, now Onward medical, since 2021 listed on Euronext Brussels and Amsterdam, and Microsure, a microsurgical robotics company). Over 25 years of experience in R&D project management, product management, creating and managing alliances, and early stage venturing, mainly for MedTech and Healthcare products.