Challenge Intervertebral disc (IVD) degeneration is one of the most prevalent causes of back/neck pain which often leads to disability for individuals of working age. Low back pain as a result of IVD degeneration is a common condition with a high impact on society, physically for the afflicted individual, as well as economically.
Opportunity Current treatment methods for degeneration-induced low back pain are fusion, and total disc replacement. Both methods do not have a sufficiently high clinical efficacy and are too often accompanied by complications. Preferably, a degenerating disc should be restored to a healthy state, i.e. regeneration. Biological interventions have so far been unsuccessful. The invention introduces porcine notochordal cell matrix as a stimulant for IVD regeneration.
Solution A protein extract isolated from the pig nucleus pulposus containing notochordal cells is solubilized and dissolved in a carrier solvent or formed as a gel. The solution can be injected into the IVD through a small gauge needle causing minimal harm.
The solution is capable of stimulating native or stem cells to multiply and thus repairing the IVD. This device can be used for the treatment of IVD degeneration in an orthopaedic setting.
Status The method of making a notochordal cell matrix solution/gel for purposes of regeneration intervertebral disc have been set up and patented. The method has been shown to stimulating native or stem cells to proliferate and to induce important constituents of the IVD in an in vivo dog model for IVD degeneration. Further validation is underway.
- Bach et al., Biologic canine and human intervertebral disc repair by notochordal cell-derived matrix: from bench towards bedside, Oncotarget, Oncotarget, 2018, Vol. 9, (No. 41), pp: 26507-26526.
- WO2017/121736A1 Notochondrial Cell Matrix as a stimulant for intervertebral disc regeneration.