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Cardiovascular

Cardiovascular

From minimally-invasive devices to novel diagnostics techniques and treatments, learn more about our cardiovascular expertise.

Cardiovascular
From invention to innovation /Cardiovascular
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We find inventions and turn them into innovations

Cardiovascular diseases remain the leading cause of death globally, taking an estimated 17.9 million lives each year. We develop ventures aimed at transforming cardiovascular care, with different focuses like diagnosis, treatment, and recovery & care. We find and select the most promising technologies at renowned knowledge institutions and corporations. Backed by an extensive network of experts and medical specialists, we meticulously assess inventions for their societal impact and financial potential. Our ultimate goal is to turn these inventions into life-changing innovations that reach and positively impact patients worldwide.

Expert-driven venture building/ cardiovascular
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Expert-driven venture building

Expert-driven venture-building NLC's robust ecosystem exemplifies our collaborative approach to venture development. Our network encompasses experts and investors from various fields, and industry partners who work alongside our inventors, clinicians, and specialists. Through expert panels and other get-togethers, our extensive ecosystem of experts and investors provides the resources necessary to elevate innovation to the next level. These experts are essential in navigating the complex healthcare landscape, offering vital support from inception to market entry.

Established partnerships for scaled impact / Cardiovascular
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Established partnerships for scaled impact

Our extensive collaborations with cardiovascular companies, key-opinion-leaders, investors, and other key stakeholders allow for the strategic development of out-of-scope assets and more. These partnerships are integral to our ecosystem, providing the necessary support structure for successful venture scaling.

Impact through innovation /Cardiovascular
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Impact through innovation

By enhancing traditional stent designs and providing clinicians with state-of-the-art software solutions, our cardiovascular initiatives lead the charge in addressing critical healthcare challenges by revolutionizing cardiovascular care. These achievements not only enhance investor value but also potentially improve health outcomes for patients globally.

Cardiovascular

portfolio

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Ago
Rapid assessment of aortic valve during surgery

AGO have developed a handy tool called the Aortic Root Pressurizing Device (ARPD) to help during heart surgeries. This device allows surgeons to check the success of aortic valve repairs while the heart is temporarily stopped. It helps avoid the need to restart the heart to check, which can be risky and time-consuming. The ARPD makes surgeries safer, quicker, and cheaper by allowing surgeons to verify their work during the operation. It's easy to use and disposable, so it doesn't add much hassle to the surgery process.

Active
🇦🇹 Austria
Cardiovascular
Ago
Artifex
Off the shelf vascular graft alternative

ArtiFex tackles a solution for coronary and peripheral bypass surgeries. Traditional grafts from the great saphenous vein face issues like rapid degeneration, leading to complications. With millions of bypass surgeries conducted annually and a billion-dollar market for vascular grafts, there's a clear need for improvement. ArtiFex's innovative vascular graft, made of cobalt-chrome and cellulose promotes tissue regeneration, strength, and ensures blood flow without causing clotting or immune reactions.

Active
🇦🇹 Austria
Cardiovascular
Artifex
Haermonics
Less complications after open-heart surgery

Haermonics addresses the challenge of complications after open heart surgery with a transformative solution. Excessive blood loss and clots post-surgery lead to numerous issues, including reoperations and cardiac tamponades, resulting in significant healthcare costs and loss of lives. The Haermonics Flush device offers a preventive approach by flushing the pericardial cavity after surgery, limiting blood loss and clot formation. By providing medical professionals with better patient status monitoring, Haermonics Flush empowers doctors to make more informed decisions, ultimately saving thousands of lives and billions in hospital costs.

Active
🇳🇱 Netherlands
Cardiovascular
Haermonics
Hapticheart Solutions
Sense of touch solution for catheter-based cardiovascular procedures

HapticHeart Solutions is revolutionizing cardiac procedures by giving cardiologists a "sense of touch" during catheter-based surgeries. These surgeries, which are becoming more complex, often require delicate maneuvers inside the heart. Their wearable device translates signals from the cath lab into tactile feedback, allowing cardiologists to feel what's happening inside the patient's heart. This helps them navigate catheters more effectively and focus on critical aspects of the procedure, leading to safer and more efficient surgeries with better outcomes for patients.

Active
🇺🇸 United States of America
Cardiovascular
Hapticheart Solutions
Kaminari Medical
Reducing re-catheterisation by analysing (unseen) plaque

Kaminari Medical is innovating coronary artery disease treatment with a catheter, combining intravascular ultrasound (IVUS) and photoacoustic imaging (PA). This IVPA technology provides precise information on plaque location and structure, enabling doctors to identify and treat dangerous plaques preemptively. By enhancing the accuracy of stent placements and guiding medication therapy, IVPA is expected to prevent 50% of re-catheterizations, reducing repeated procedures and saving over €1 billion annually.

Active
🇳🇱 Netherlands
Cardiovascular
Kaminari Medical
Nicolab
Image analysis for the improvement of stroke treatment

Nicolab tackles the challenge of stroke diagnosis and treatment by offering computational support through their portfolio of six algorithms. These algorithms analyze radiological images of acute stroke patients, providing fast and objective interpretation for physicians. With stroke affecting millions annually and significant economic burdens, Nicolab's solution improves decision-making speed and accuracy, allowing clinicians to assess stroke severity objectively and make timely treatment decisions.

Active
🇳🇱 Netherlands
Cardiovascular
Nicolab
Nilocas
A cardiac device for the detection of coronary artery disease

Nilocas offers a revolutionary solution for detecting coronary artery disease non-invasively and without radiation. Patients wear a lightweight chest patch that captures the sounds of turbulent blood flow through arteries using microphones and accelerometers. Advanced machine learning and AI rapidly analyze the data, providing a clear diagnosis in just 10 minutes. This innovation eliminates the need for costly and invasive procedures, making cardiac diagnosis more accessible in both clinical and non-clinical settings.

Active
🇬🇧 United Kingdom
Cardiovascular
Nilocas
Occlunova
An implantable device for people with chronic atrial fibrillation (AF)

OCCLUNOVA introduces a novel solution for chronic atrial fibrillation (AF), a condition affecting millions worldwide where the heart's upper chambers beat irregularly. Their implantable device aims to prevent strokes associated with AF by sealing off the left atrial appendage (LAA), where blood clots often form. Unlike traditional methods, which can cause complications due to their rigid frame, OccluNova's design uses a flexible balloon to fully seal the LAA. This innovative approach minimizes risks like pericardial effusions and incomplete closure, offering a safer option for AF patients.

Active
🇺🇸 United States of America
Cardiovascular
Occlunova
ProVascTec
Transforming arterial disease treatment with cell therapy

ProVascTec offers a novel solution for chronic arterial disease, focusing on peripheral arterial disease (PAD) and chronic limb ischemia. Unlike traditional treatments like angioplasty or bypass surgery, ProVascTec aims to stimulate vascular tissue growth using mesenchymal stem cells, reducing complications and improving blood flow. This innovative approach has the potential to benefit millions of patients suffering from PAD worldwide.

Active
🇮🇪 Ireland
Biotech
Cardiovascular
ProVascTec
Startric
Revolutionizing tricuspid valve repair with minimally invasive solutions

StarTric, created by cardiovascular experts, developed a new, less invasive device to fix a serious heart valve problem, Tricuspid Regurgitation (TR). Addressing Tricuspid Regurgitation (TR), a severe condition with high mortality rates, StarTric's device offers a safer alternative to open-heart surgery. The technology can be implanted via a transfemoral catheter, combining the safety of minimally invasive methods with the proven efficacy of the Clover technique, aiming to provide effective treatment to millions of TR patients worldwide who currently lack suitable options.

Active
🇮🇹 Italy
Cardiovascular
Startric
Venous Stent
World's first in length adjustable multi-segmented venous stent

The Venous Stent is a new type of stent designed to help with conditions like deep vein thrombosis (DVT) and post-thrombotic syndrome (PTS). Unlike older stents, this one can adjust in length and has multiple parts, making it more flexible and better for the veins. It helps improve blood flow and healing in the veins, potentially reducing the need for long-term medication.

Active
🇳🇱 Netherlands
Cardiovascular
Venous Stent

Our impact

100+
Inventions assessed annually
13
Active portfolio ventures
€45M+
Raised by NLC ventures
235K+
Patients impacted
2
Ventures in clinical trials or commercialization stage
8
Countries active in

Explore our 2023 Impact report

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Erasmus Medisch Centrum
Mayo Clinic
Mount Sinai Hospital
AMC
Philips
Terumo
Oxford
Universitätsspital Basel
Dave Koolbergen, MD, PhD
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As a physician, I lack the knowledge and expertise to start a business and don’t have the time to learn how to. NLC has this expertise, and can cover the business aspects for me so I can still focus on my clinical work.
Dave Koolbergen, MD, PhD

Dave Koolbergen, MD, PhD

Congenital Cardiac Surgeon, AMC & Chief Medical Officer, HAERMONICS

Dr. Ludo Beenen
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One of the most important things StrokeViewer from Nicolab does for me is the transfer of information of patients between hospitals and radiologists, which can save so much time.
Dr. Ludo Beenen

Dr. Ludo Beenen

Trauma and Emergency Radiologist, Amsterdam UMC

Build health with us

Alessandro Radaelli
Alessandro Radaelli
Lead Cardiovascular, Venture Partner
Henk Westendorp
Henk Westendorp
Lead Expertise Integration, Venture Partner

Meet the team

Alessandro Radaelli
Alessandro Radaelli
Alessandro Radaelli
Lead Cardiovascular, Venture Partner
Henk Westendorp
Henk Westendorp
Henk Westendorp
Lead Expertise Integration, Venture Partner
Ellis Aune
Ellis Aune
Ellis Aune
Venture Developer
Lars Olthof
Lars Olthof
Lars Olthof
Investment Manager
Wijna Bekker
Wijna Bekker
Wijna Bekker
CEO Recruiter
Nino Chirico
Nino Chirico
Nino Chirico
Venture Developer