Ventures

Spinal cord Injury represents a large unmet medical need with approximately 1.2M new cases per year resulting mainly from motor vehicle accidents, falls and water related accidents. Currently available treatments only offer symptomatic relief but do not target the underlying pathophysiologic changes. The spinal cord injury market is predicted to reach US$3B by 2025. MLP-1236 is a First in class dual inhibitor of matrix metalloproteinases (MMP) 9 and MMP 12 and has already completed Phase 1 and Phase 2a clinical studies. In preclinical models, MLP-1236 was effective in preventing/reversing the neurodegeneration associated with spinal cord injury and ischemic stroke.

MLA Diagnostics improves melanoma diagnosis, offering personalized measurement of malignancy levels. Traditional diagnosis often leads to overtreatment or undertreatment, resulting in patient distress or undetected cancer progression. By analyzing methylation, our test provides accurate prognosis, enabling tailored treatment plans and saving lives. With the melanoma therapeutics market on the rise, our innovative solution is poised to make a significant impact, improve patient outcomes and create opportunities.

MindAffect aims to diagnose visual and hearing impairments in over 2 billion people, including children, seniors, and the disabled, leading to untreated impairments and significant societal costs. Their innovative brain computer interface and AI technology offer a solution by analyzing brain responses to auditory or visual stimuli, reducing testing time and improving accuracy.

ProVascTec offers a novel solution for chronic arterial disease, focusing on peripheral arterial disease (PAD) and chronic limb ischemia. Unlike traditional treatments like angioplasty or bypass surgery, ProVascTec aims to stimulate vascular tissue growth using mesenchymal stem cells, reducing complications and improving blood flow. This innovative approach has the potential to benefit millions of patients suffering from PAD worldwide.

Haermonics addresses the challenge of complications after open heart surgery with a transformative solution. Excessive blood loss and clots post-surgery lead to numerous issues, including reoperations and cardiac tamponades, resulting in significant healthcare costs and loss of lives. The Haermonics Flush device offers a preventive approach by flushing the pericardial cavity after surgery, limiting blood loss and clot formation. By providing medical professionals with better patient status monitoring, Haermonics Flush empowers doctors to make more informed decisions, ultimately saving thousands of lives and billions in hospital costs.

Heat2Move offers a revolutionizing approach to chronic back pain treatment. Unlike traditional methods relying on medications or heat patches, Heat2Move combines blue light and infrared warmth to enhance blood flow and muscle repair. This innovative solution provides therapists and patients with a new tool for managing chronic pain effectively. With its potential to make a significant impact on treatment options, BlueTouch offers hope for those suffering from back pain worldwide.

Epilepsy causes uncontrolled seizures, greatly reducing quality of life and sometimes leading to early death. Over 50 million people worldwide have epilepsy, but only two-thirds respond to medication. For those with drug-resistant epilepsy, treatment options are limited and often ineffective. MIR Therapeutics is developing a new gene therapy to provide lasting and powerful seizure control for drug-resistant epilepsy patients. Their therapy delivers microRNA-335 to the affected brain regions using an AAV9 viral vector, which helps control hyperexcitability by regulating voltage-gated sodium channels. This results in fewer and less severe seizures.

Porous GmbH has developed an ultrasound technology that accurately diagnoses cortical bone health, addressing the limitations of traditional methods. Osteoporosis affects millions globally, leading to frequent and costly fractures. Current diagnostics often miss early-stage bone deterioration, but Porous GmbH’s patented algorithms allow ultrasound to measure bone quality at a microscopic level for a safer and more precise method for early detection of osteoporosis, also reducing healthcare costs.