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Orthopedics & Spine

Orthopedics & Spine

From hip technologies to spine implants and diagnostic imaging for osteoporosis, learn more about our ortho-spine expertise.

Orthopedics & Spine
We find inventions / Ortho
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We find inventions and turn them into innovations

Orthopedic and spine diseases and injuries are significant causes of disability worldwide, affecting millions with severe impairments. Our Orthopedics & Spine team focuses on advancing the field by fostering early-stage innovations that span diagnosis, treatment, and rehabilitation. We find the most promising technologies at renowned institutions and corporations. Leveraging our extensive network of experts and medical specialists, we carefully evaluate each invention for its potential societal impact and commercial viability, and only the best we decide to build into a venture.

Expert-driven venture building  / Ortho
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Expert-driven venture building

NLC's robust ecosystem exemplifies our collaborative approach to venture development. Our network encompasses experts and investors from various fields, and industry partners, such as the Mayo Clinic and the University of Manchester, who work alongside our inventors, clinicians, and specialists. Through expert panels and other get-togethers, our extensive ecosystem of experts and investors provides the resources necessary to elevate innovation to the next level. These experts are essential in navigating the complex healthcare landscape, offering vital support from inception to market entry.

Established partnerships.... / Ortho
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Established partnerships for scaled impact

Our numerous partnerships with leading organizations such as Stryker and Medtronic, facilitate strategic development beyond conventional scope. These partnerships are integral to our ecosystem, providing the necessary support structure to effectively scale our orthopedic and spine ventures.

Orthopedics & Spine

portfolio

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Altach
Off-the-shelf solution for improved cartilage repair

Altach is tackling the challenge of treating damaged cartilage effectively without costly or complex procedures. Altach's solution is a simple, ready-to-use implant that makes microfracture treatment better. It's made from cartilage-like material and helps the body build new, healthy cartilage. This means fewer surgeries and better outcomes for patients.

Active
🇮🇪 Ireland
Orthopedics & Spine
Altach
Amotio
Easier joint implant revision surgery through 3D technology

Amotio addresses the challenge of revision surgeries for hip, knee, and shoulder implants with their innovative approach. Collaborating with expert revision surgeons and guided by NLC, they offer a patented solution for improved implant revision surgery. By developing unique bone cement removal devices and integrating advanced patient-specific 3D surgical planning and printing technology, Amotio aims to set a new standard for excellence in these surgeries. Their goal is to reduce complexity, trauma, and recovery time while cutting costs for healthcare providers.

Active
🇳🇱 Netherlands
Orthopedics & Spine
Amotio
Axial
Bone repair system reduces pain after surgery and brings better recovery

Axial Orthopaedics Inc. revolutionizes trauma treatment with their innovative intramedullary nailing system. Current systems often lead to bone misalignment and joint pain, blocking post-procedural recovery. Axial Orthopaedics's modular system offers greater flexibility in bone alignment and healing. This system not only addresses postoperative pain but also reduces complications. Its intra-operative modularity and rotational capabilities allow surgeons to achieve better fracture fixation and improved outcomes, filling a crucial gap in current technology.

Active
🇺🇸 United States of America
Orthopedics & Spine
Axial
Garland Surgical
Novel hip implant designed to last

Garland Surgical addresses the challenge of hip replacement surgeries by offering an innovative solution that improves upon standard prostheses. Unlike traditional implants, the MaltaHip features four independent parts that provide enhanced mobility in three directions, reducing wear and minimizing the risk of dislocation. This implant offers a longer lifespan and greater functionality compared to standard prostheses. Importantly, it doesn't require a change to the normal surgical procedure, making it easier for surgeons to adopt.

Active
🇬🇧 United Kingdom
Orthopedics & Spine
Garland Surgical
Implant Preservation Devices (IPD)
Heating device for treatment of implant infections

Implant Preservation Devices has developed a handheld device to tackle a common problem after joint replacement surgeries prosthetic joint infections (PJI). This device applies heat to implants using induction, effectively targeting and eliminating bacteria that cause these infections. By reducing the risk of recurrent infections, it offers a quick, sterile, and convenient treatment option during surgery, potentially benefiting patients beyond just those undergoing joint replacements.

Active
🇳🇱 Netherlands
Orthopedics & Spine
Implant Preservation Devices (IPD)
Implantguard
Process to prevent bacterial infections of medical implants

ImplantGuard is addressing the challenge of bacterial infections post-implant surgery, which affect millions of patients worldwide. Their solution involves coating implants with antimicrobials using a versatile and cost-effective process called plasma nitriding. This innovative coating technology offers a safer and more efficient alternative to existing implant coatings, potentially reducing the risk of infections and the need for costly surgical procedures.

Active
🇦🇹 Austria
Orthopedics & Spine
Implantguard
Liftya
Unique personalized shoulder assisting device

Introducing Liftya, a solution for shoulder instability. Developed with a patented spherical hinge mechanism, Liftya mimics the natural shoulder joint movement, offering stability and full range of motion. Unlike traditional braces, Liftya promotes motor recovery and independence, reducing pain and healthcare costs for patients.

Active
🇩🇰 Denmark
Orthopedics & Spine
Liftya
NC Biomatrix
Regeneration of intervertebral disc as treatment for low back pain

NC Biomatrix offers a solution for treating low back pain caused by intervertebral disc (IVD) degeneration. Current treatments often come with complications and limited effectiveness. NC Biomatrix introduces an approach using a protein extract from pig nucleus pulposus, that stimulate disc regeneration. This extract provides a scaffold for natural tissue repair without damaging the surrounding. This injectable treatment aims to restore the degenerated disc, offering hope for effective relief from low back pain.

Active
🇳🇱 Netherlands
Biotech
Orthopedics & Spine
NC Biomatrix
Porous Gmbh
Assessing cortical bone health with ultrasound

Porous GmbH has developed an ultrasound technology that accurately diagnoses cortical bone health, addressing the limitations of traditional methods. Osteoporosis affects millions globally, leading to frequent and costly fractures. Current diagnostics often miss early-stage bone deterioration, but Porous GmbH’s patented algorithms allow ultrasound to measure bone quality at a microscopic level for a safer and more precise method for early detection of osteoporosis, also reducing healthcare costs.

Active
🇩🇪 Germany
Orthopedics & Spine
Porous Gmbh
Retendon
Improving tendon repair with a two-part solution

Retendon offers an innovative solution for tendon injuries, addressing challenges in both retrieval and repair processes. Its two-part system includes a tendon retrieval device, minimizing trauma and adhesion formation during tendon retrieval, and a tendon augmentation device, enabling rapid reconnection with more even stress distribution for better functional outcomes and faster recovery. With hand injuries causing a significant portion of emergency visits and current treatments often resulting in scarring and functional loss, Retendon's approach could significantly improve patient outcomes across various tendon injuries.

Active
🇬🇧 United Kingdom
Orthopedics & Spine
Retendon
Theragenix
Bone repair technology using gene therapy during surgery

TherageniX introduces an approach to improve bone implants by augmenting autologous bone grafts with regenerative gene therapies. Traditional bone repair methods face challenges like rejection, infection, and limited regenerative capacity. TherageniX's solution aims to enhance the regenerative bone grafts, improving functional outcomes and reducing donor trauma. This method bypasses regulatory and manufacturing hurdles, offering a promising advancement in bone grafting procedures.

Active
🇬🇧 United Kingdom
Biotech
Orthopedics & Spine
Theragenix

Our impact

100+
Inventions assessed annually
10
Active portfolio ventures
8
Countries active in
2
Ventures in clinical trials or commercialization stage
500
Patients impacted

Explore our 2023 Impact report

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Aalborg University
Charite
Conectus
Leiden Universitair Medisch Centrum
Mayo Clinic
Queen Mary University of London
Trinity College Dublin
Technische Universiteit Eindhoven
Universitair Medisch Centrum Utrecht
University of Malta
University of Manchester
University of Nottingham
Simon Mifsud
Starting as a CEO of a pre-revenue start-up poses many individual challenges. Sharing experiences helps us to accelerate our progress. Having a community of like-minded entrepreneurs makes it feel like you are part of a larger ecosystem.
Simon Mifsud

Simon Mifsud

CEO Garland Surgical

Richard van de Wateringen
The support network within our ortho spine Cluster is unparalleled. Collaborating with fellow CEOs has provided fresh perspectives. Expert advice is just a phone call away, ensuring swift progress.
Richard van de Wateringen

Richard van de Wateringen

CEO Implant Preservation Devices (IPD)

Julia Eschenbrenner
Being part of the ortho spine cluster has been invaluable. Learning from fellow CEOs navigating similar challenges is unparalleled. Plus, having experts readily available has accelerated our growth.
Julia Eschenbrenner

Julia Eschenbrenner

CEO POROUS

get in touch to build a healthier future

Kim High
Kim High
Venture Partner
Annabel van der Horst
Annabel van der Horst
Venture Developer