The Netherlands
Devices for treatment


Chronic Obstructive Pulmonary Disease (COPD) is an incurable and progressive disease characterized by a persistent reduction of airflow in lungs. For patients suffering from this disease, it becomes harder and harder to breathe. As the disease gets worse, shortness of breath makes it harder to remain active. That is why patients become more sedentary in the long term and they are advised to be more active. Even a light exercise may lead to dyspnea (shortness of breath) which in turn may lead to hospitalization(s). 


The standard treatment for COPD is steroid-based inhalers which temporarily improve lung function. They do a good job at managing the condition, but the #1 unmet need for COPD patients is their inability to perform light exercise, such as going for short walks or walking up stairs. Rescue inhalers show effect after some delay which does not help dyspnea instantaneously. Besides, patients risk steroid overdose as the frequency of usage rises.


With a customer-centred method to determine the biggest pains suffered by COPD patients, a pNIV (portable non-invasive device) was created. It is a handheld bilevel continuous positive airway pressure (CPAP) device that provides relief from activity-related shortness of breath with a drug-free therapy. It overcomes the problem of dynamic hyperinflation by providing an assistive pressure on inhalation and maintaining that the airways are opened on exhalation. This improves patients’ quality of life, increases their confidence in their social lives and provides faster relief with more exercise opportunities.


The pNIV has received very positive patient feedback. The next steps include determining the right go-to-market strategy and geographical focus (including potentially FDA approval) and gathering the right clinical evidence to support this. 

Meet the team


Ton Tijn Hulleman


Pieter Wijffels (1)

Pieter Wijffels

Venture Partner

Pieter joined NLC in April 2020 as a Venture Partner. Before joining NLC, he spent 15 years at Philips, bringing innovation to life across the globe. He enjoys working in fast-paced environments and supporting initiatives that truly improve people’s lives.