Since
2020
France
Therapeutics
TRL 4

Challenge

The knee is one of the largest and most complex joints in our body. The cartilage in our knees is a crucial part that does the most load-bearing of the weight. To this date, cartilage damage in the knee affects millions of people worldwide with a continued rise in incidence. Since cartilage does not have self-healing capabilities, the mobility of these patients is on the path to be drastically and permanently impeded.

Opportunity

Currently, the only conventional solutions are symptoms (pain, stiffness) management, microfracture and in the end, micentirely replacing the joint with a prosthesis. Lately, cell therapies have emerged as a solution to regenerate cartilage e.g. tissue engineered autologous chondrocyte implantations (ACIs). ACIs, though less invasive, face the problem that recovery is very slow and produce low quality cartilage. This makes that these implants often fail to integrate with the surrounding tissue which results to failure rates up to 36%.

Solution

Researchers from the Strasbourg University and Inserm have invented ARTiREG. This new cell therapy aims to improve the cell approach by an innovative scaffold that houses Mesenchymal stem cells (MSCs) for optimal regeneration of the cartilage. By combining this patented scaffold together with growth factors and the MSCs, the product ensures fast recovery and high quality cartilage.

Status

This approach has been proven to reach superior bone tissue formation in vitro as well as in vivo, following implantation in a animal bone defect model. As the product is finished with the preclinical phase, it is ready to initiate the phase I/II trials.

Meet the team

Ineke-150x150

Ineke Rijnhout

CEO

Milad

Milad Tannazi

Venture Developer at NLC

Pharmacist by training and with various entrepreneurial endeavours during his studies he acquired the skills to bring projects forward. Therefore, he is very eager to use these skills to bring technology, health and business together to drive change and innovation for the patient.

Denis

Denis Hansjacob

Venture Partner at NLC

Cardio and Neuro Vascular expert, with 30 years experience in executive roles in the medical device industry in Europe.