Our
portfolio

The challenge with lung cancer lies in its late detection, often leading to unfortunate outcomes. Current screening methods like low-dose CT scans are costly and have radiation risks, while blood tests lack accuracy or are too expensive. Our solution offers a non-invasive blood test that detects lung cancer early with high sensitivity and specificity. This test, with its multi-protein panel, can identify even stage I cancer, improving survival rates and reducing unnecessary procedures.

Aetherus tackles COPD, a debilitating lung disease, with their portable, non-invasive (pNIV) device. This device offers instant relief from breathlessness, improving patients' daily lives without adding to treatment regimens or causing side effects. By empowering patients to manage breathlessness anytime, anywhere, the pNIV device enhances COPD management and quality of life. This not only benefits patients but also alleviates the burden on healthcare systems, families, employers, and society at large.

AGO have developed a handy tool called the Aortic Root Pressurizing Device (ARPD) to help during heart surgeries. This device allows surgeons to check the success of aortic valve repairs while the heart is temporarily stopped. It helps avoid the need to restart the heart to check, which can be risky and time-consuming. The ARPD makes surgeries safer, quicker, and cheaper by allowing surgeons to verify their work during the operation. It's easy to use and disposable, so it doesn't add much hassle to the surgery process.

AIDO enhances precision control during endoscopic procedures with its drive unit. Physicians can now maintain control of the endoscope shaft while operating tools, saving time and improving efficiency. This platform technology streamlines the control of instruments inserted through the endoscope's working channel, offering automatic insertion and precise control, ultimately improving patient safety and procedural outcomes.

AiSentia addresses the challenge of using contrast dye in CT scans. They've developeda patient-centric solution that eliminates the need for contrast agents and reduces associated risks like patient discomfort, allergic reactions, and radiation exposure. Their technology uses AI to get more information from regular CT scans, making them safer for checking arteries. Since approximately 2% of the population suffers from conditions such as contrast-induced nephropathy or kidney failure, AiSentia's technology makes CTA scans more accessible while seamlessly integrating into existing clinical workflows.

Allergios revolutionizes allergy diagnosis by directly visualizing the allergic response in patient blood, offering a more accurate alternative to current tests like skin prick and IgE blood tests. Additionally by analyzing how blood serum reacts to allergens. With its disposable chip, optical reader, and AI-based analysis software, Allergios helps millions of allergy sufferers worldwide access timely and effective treatment options.

Altach is tackling the challenge of treating damaged cartilage effectively without costly or complex procedures. Altach's solution is a simple, ready-to-use implant that makes microfracture treatment better. It's made from cartilage-like material and helps the body build new, healthy cartilage. This means fewer surgeries and better outcomes for patients.

Amotio addresses the challenge of revision surgeries for hip, knee, and shoulder implants with their innovative approach. Collaborating with expert revision surgeons and guided by NLC, they offer a patented solution for improved implant revision surgery. By developing unique bone cement removal devices and integrating advanced patient-specific 3D surgical planning and printing technology, Amotio aims to set a new standard for excellence in these surgeries. Their goal is to reduce complexity, trauma, and recovery time while cutting costs for healthcare providers.

Angiogenesis Analytics, offers an ultrasound-based solution for detecting, localizing, and characterizing prostate cancer. Each year, over 1.5 million men undergo invasive biopsies with risks of infection, false negatives, and overtreatment. Angiogenesis Analytics eliminates these issues by providing a non-invasive, accurate, and cost-effective alternative, improving patient comfort and outcomes. With an estimated market value of USD 450 million annually, Angiogenesis Analytics addresses a significant global need for better prostate cancer diagnostics.

Ansana offers a smart sterilization container for surgical instruments, designed to tackle key challenges in the healthcare sector. By integrating electronic sensors, it ensures sterility in operating rooms, reducing the risk of infections by 10% and lowering the environmental impact of sterilization processes by 85%. Ansana's enhances patient safety with real-time monitoring and traceability features, with complex instruments like endoscopes, while also cutting costs for healthcare facilities in terms of labor and materials.

Arne enhances urgent neonatal care by using augmented reality and artificial intelligence to provide real-time clinical decision support. In stressful situations, doctors can miss critical protocol steps, but Arne’s smart software projects recommends actions directly into the doctor's field of vision, reducing errors and improving patient outcomes. This innovative tool ensures every newborn receives optimal care, while empowering neonatologists.

ArtiFex tackles a solution for coronary and peripheral bypass surgeries. Traditional grafts from the great saphenous vein face issues like rapid degeneration, leading to complications. With millions of bypass surgeries conducted annually and a billion-dollar market for vascular grafts, there's a clear need for improvement. ArtiFex's innovative vascular graft, made of cobalt-chrome and cellulose promotes tissue regeneration, strength, and ensures blood flow without causing clotting or immune reactions.

The rising number of surgeries in healthcare systems like the National Health Service is challenging due to increasing demand and backlogs. However, new solutions like the Asclepius Platform aim to streamline assessments before and after surgery using digital tools and AI. By analyzing patient data, it helps doctors make better decisions, reduce complications, and improve patient outcomes. Designed with input from patients, it's a cost-effective way to make surgery safer and more efficient.

Aspect Neuroprofiles is tackling the challenges of diagnosing and treating Autism Spectrum Disorder (ASD) by combining EEG technology with Artificial Intelligence. Their method objectively measures brain activity related to ASD, improving diagnosis accuracy and predicting treatment effectiveness. This approach aims to shift from subjective assessments to objective physiological measurements, offering hope for millions affected by ASD and mental health issues.

Axial Orthopaedics Inc. revolutionizes trauma treatment with their innovative intramedullary nailing system. Current systems often lead to bone misalignment and joint pain, blocking post-procedural recovery. Axial Orthopaedics's modular system offers greater flexibility in bone alignment and healing. This system not only addresses postoperative pain but also reduces complications. Its intra-operative modularity and rotational capabilities allow surgeons to achieve better fracture fixation and improved outcomes, filling a crucial gap in current technology.

Bilihome aims to revolutionize jaundice treatment for newborns by bringing safe and effective phototherapy from the hospital to the comfort of home. Currently, traditional methods require babies to be isolated in hospitals, disrupting bonding and caregiving between parents and infants. Bilihome's solution integrates blue light therapy into a comfortable garment, allowing newborns to receive treatment while being held, breastfed, and cared for as usual. This patient-centered innovation enables natural care at home, freeing up hospital bed space and promoting family-centric care.

BiteOn has devised a breakthrough in dental implants: personalized implants tailored to each patient's jawbone structure. Traditional bone graft procedures are costly and painful, often extending treatment time by six months. BiteOn's solution eliminates the need for bone grafts by designing implants based on 3D scans of the patient's mouth. This innovation promises quicker, less painful, and more successful dental replacements, offering hope to patients previously unable to undergo traditional procedures.

Capnosway introduces a CO2 monitoring device designed to address the shortcomings of traditional anesthesia. Developed by Philips, this solution directly measures CO2 concentration at the patient's mouth or nose without the need for air sampling. By eliminating procedures, and potential errors associated, Capnosway ensures accurate and efficient monitoring for medical professionals.

ChARM, or the Children’s Automated Respiration Monitor, addresses the challenge of pneumonia misdiagnosis in low-resource settings. This battery-powered device provides accurate breathing rate monitoring for children under five, empowering healthcare workers to make correct diagnoses swiftly. By streamlining the diagnostic process, ChARM facilitates timely treatment, potentially saving thousands of young lives annually.

The traditional practice of immediately cutting the umbilical cord after birth can pose risks to newborns, causing a dangerous drop in blood flow and oxygen levels. Concord Neonatal offers a solution by allowing babies to receive lifesaving care with the umbilical cord intact until they start breathing on their own. This innovation, aims to prevent birth complications and long-term disabilities, while keeping the baby close to the mother and maximizing the benefits of placental blood until the baby can breathe independently.

Crainio pioneers intracranial pressure (ICP) monitoring, for assessing traumatic brain injuries (TBI) without invasive procedures. Traditional methods involve drilling into the skull, posing risks. Crainio's method uses a forehead probe and a technique called photoplethysmography to measure pulse signals. This gives real-time estimates of ICP without invasive procedures. With TBI being a leading cause of death and disability, Crainio's innovation will potentially revolutionize TBI management.

DiaphOne Therapeutics is developing treatments for diabetic complications and neurodegenerative diseases. The company develops first-in-class small molecule RAGE antagonists that target the intracellular RAGE-DIAPH1 pathway, showing improved efficacy over extracellular approaches. Backed by NLC Health Ventures, DiaphOne Therapeutics leverages cutting-edge research from NYU Langone Health and The University at Albany, SUNY and has demonstrated promising proof of concept preclinical results. Currently advancing lead optimisation studies, DiaphOne is bringing forward curative therapies for diabetic complications and neurodegeneration, with the support of NLC’s Health Impact Fund for its preclinical development.

Ecomedic is dedicated to helping hospitals reduce their carbon footprint, addressing the healthcare sector's contribution to global emissions. Ecomedic's database and software tools enable environmental impact analyses, identify sources of emissions and measures the effect of alternative solutions. By providing insights and solutions, the institutions are supported in achieving their carbon neutrality goals and reducing operational costs.

Exolvo Biosciences, a collaboration between NLC Health Ventures and Verily (Google) Life Sciences, is revolutionizing oral drug delivery for large molecules like biologics. Our smart capsule technology, originating from the Google X moonshot program, eliminates painful injections and maximizes medication effectiveness. With ongoing pre-clinical testing and plans for an IND package in the U.S., we're poised to redefine drug delivery standards.

Flash Pathology revolutionizes tissue assessment with its scanner, with immediate imaging of biopsy and surgical specimens in the moment of operation. Unlike traditional methods, taking hours and requiring extensive labor, the Flash Pathology scanner visualizes cell structures within seconds without any preparation. This, non-labor-intensive solution enables distinguishing healthy tissue from tumors in real-time, reducing the need for revision surgeries and unnecessary biopsies.

FlowView Diagnostics addresses the challenge of analyzing complex cell data from blood samples using multiparameter flow cytometry, vital for conditions like leukemia monitoring. They tackle this with an algorithm that quickly processes raw data, detecting Minimal Residual Disease (MRD) more accurately and rapidly than manual methods. In a case study, the algorithm analyzed 8 million cells in 2 minutes, presenting simplified results for quicker interpretation, reducing the risk of false negatives, and enhancing efficiency in leukemia monitoring.

Foveo Fertility addresses the challenge of improving in vitro fertilization (IVF) success rates by providing a stable physiological environment for egg cells. Unlike current methods that expose egg cells to air, leading to cooling and evaporation, Foveo Fertility ensures consistent conditions for optimal egg cell quality. This innovation also streamlines workflow in the IVF lab, reducing human error and saving time for embryologists. With no other product on the market offering constant physiological conditions for egg cells, Foveo Fertility aims to improve the lives of both lab workers and patients by maximizing the potential for successful pregnancies.

Garland Surgical addresses the challenge of hip replacement surgeries by offering an innovative solution that improves upon standard prostheses. Unlike traditional implants, the MaltaHip features four independent parts that provide enhanced mobility in three directions, reducing wear and minimizing the risk of dislocation. This implant offers a longer lifespan and greater functionality compared to standard prostheses. Importantly, it doesn't require a change to the normal surgical procedure, making it easier for surgeons to adopt.

Haermonics addresses the challenge of complications after open heart surgery with a transformative solution. Excessive blood loss and clots post-surgery lead to numerous issues, including reoperations and cardiac tamponades, resulting in significant healthcare costs and loss of lives. The Haermonics Flush device offers a preventive approach by flushing the pericardial cavity after surgery, limiting blood loss and clot formation. By providing medical professionals with better patient status monitoring, Haermonics Flush empowers doctors to make more informed decisions, ultimately saving thousands of lives and billions in hospital costs.

HapticHeart Solutions is revolutionizing cardiac procedures by giving cardiologists a "sense of touch" during catheter-based surgeries. These surgeries, which are becoming more complex, often require delicate maneuvers inside the heart. Their wearable device translates signals from the cath lab into tactile feedback, allowing cardiologists to feel what's happening inside the patient's heart. This helps them navigate catheters more effectively and focus on critical aspects of the procedure, leading to safer and more efficient surgeries with better outcomes for patients.

Heat2Move offers a revolutionizing approach to chronic back pain treatment. Unlike traditional methods relying on medications or heat patches, Heat2Move combines blue light and infrared warmth to enhance blood flow and muscle repair. This innovative solution provides therapists and patients with a new tool for managing chronic pain effectively. With its potential to make a significant impact on treatment options, BlueTouch offers hope for those suffering from back pain worldwide.

Hemeo addresses the challenge of treating ICU patients with coagulation issues by developing a decision support system. This system uses patient data and real-time monitoring to accurately assess bleeding and thrombosis risks. By modeling the coagulation system with a smart algorithm, it provides personalized recommendations to clinicians, helping them make more informed therapy decisions. With ICU patients at high risk for venous thromboembolism and bleeding incidents, this solution aims to improve patient outcomes and reduce uncertainty in treatment.

Implant Preservation Devices has developed a handheld device to tackle a common problem after joint replacement surgeries prosthetic joint infections (PJI). This device applies heat to implants using induction, effectively targeting and eliminating bacteria that cause these infections. By reducing the risk of recurrent infections, it offers a quick, sterile, and convenient treatment option during surgery, potentially benefiting patients beyond just those undergoing joint replacements.

ImplantGuard is addressing the challenge of bacterial infections post-implant surgery, which affect millions of patients worldwide. Their solution involves coating implants with antimicrobials using a versatile and cost-effective process called plasma nitriding. This innovative coating technology offers a safer and more efficient alternative to existing implant coatings, potentially reducing the risk of infections and the need for costly surgical procedures.

Innofuse is revolutionizing care for the most fragile among us: preterm infants in Neonatal Intensive Care Units (NICUs). Their innovative Tulive® IV-set ensures these tiny patients receive medication with precision and immediacy, sparing them from the risks of inaccurate or delayed drug administration. By reducing fluctuations and eliminating overshoot, Tulive® safeguards against potential brain damage, offering hope and reassurance to families in NICUs worldwide.

Intuescope, develops advanced tools to make endoscopy and colonoscopy procedures faster and safer. Despite being gold standard tests, traditional scopes have changed little over 40 years and often miss abnormalities. Intuescope's innovations aim to reduce procedure time, enhance detection accuracy, and support doctors with more automation, addressing the growing need for efficient and reliable endoscopic solutions.

Kaminari Medical is innovating coronary artery disease treatment with a catheter, combining intravascular ultrasound (IVUS) and photoacoustic imaging (PA). This IVPA technology provides precise information on plaque location and structure, enabling doctors to identify and treat dangerous plaques preemptively. By enhancing the accuracy of stent placements and guiding medication therapy, IVPA is expected to prevent 50% of re-catheterizations, reducing repeated procedures and saving over €1 billion annually.

Karla Therapeutics is exploring an approach, treating mental disorders by leveraging our immune system. Neurodevelopmental disorders like ADHD and OCD are increasingly prevalent, yet treatment options often have side effects and limited effectiveness. By bridging between the immune system and mental health, Karla aims to revolutionize treatment methods. Their research focuses on a specific protein identified by top-tier immunologists, showing promising results in early experiments for OCD, anxiety, and ADHD.

Lamina offers a solution for the regeneration of cartilage, addressing a prevalent issue affecting millions worldwide. Traditional treatments focus on symptom management or procedures like joint replacement, with limited success. Lamina's ARTiREG, enhances cell therapy with a special framework to hold Mesenchymal stem cells which repair for the body and help fix damaged cartilage. This patented approach promotes fast recovery, potentially transforming outcomes for individuals with cartilage damage.

Introducing LarynxLock, prevents air leaks during surgery with a gentle pressure on the mouth's base, ensuring patients receive uninterrupted air supply. LarynxLock not only safeguards patients from complications but also reduces physical strain and surgery duration, offering a smart and cost-effective solution for improved surgical outcomes.

Introducing Liftya, a solution for shoulder instability. Developed with a patented spherical hinge mechanism, Liftya mimics the natural shoulder joint movement, offering stability and full range of motion. Unlike traditional braces, Liftya promotes motor recovery and independence, reducing pain and healthcare costs for patients.

Laparoscopic surgery, while effective, faces limitations in low-resource areas due to cost and sustainability concerns associated with CO2 insufflation. Gasless laparoscopy provides an alternative, that are costly and difficult to use. To address these challenges, LORESA has developed an affordable and user-friendly gasless laparoscopy retractor, designed with input from surgeons worldwide, offering improved usability and cost-effectiveness. This innovation, aims to democratize laparoscopic techniques, benefiting rural hospitals and developing communities.

Lumabs introduces a revolutionary diagnostic platform offering quick and precise biomolecule measurement right at the point of care. By eliminating the need for time-consuming laboratory processes, such as ELISA tests, Lumabs ensures patients receive vital diagnostic results immediately. This innovation is crucial in emergency and intensive care settings, where real-time information can guide rapid treatment decisions, potentially saving lives.

Epilepsy causes uncontrolled seizures, greatly reducing quality of life and sometimes leading to early death. Over 50 million people worldwide have epilepsy, but only two-thirds respond to medication. For those with drug-resistant epilepsy, treatment options are limited and often ineffective. MIR Therapeutics is developing a new gene therapy to provide lasting and powerful seizure control for drug-resistant epilepsy patients. Their therapy delivers microRNA-335 to the affected brain regions using an AAV9 viral vector, which helps control hyperexcitability by regulating voltage-gated sodium channels. This results in fewer and less severe seizures.

MLA Diagnostics improves melanoma diagnosis, offering personalized measurement of malignancy levels. Traditional diagnosis often leads to overtreatment or undertreatment, resulting in patient distress or undetected cancer progression. By analyzing methylation, our test provides accurate prognosis, enabling tailored treatment plans and saving lives. With the melanoma therapeutics market on the rise, our innovative solution is poised to make a significant impact, improve patient outcomes and create opportunities.

Spinal cord Injury represents a large unmet medical need with approximately 1.2M new cases per year resulting mainly from motor vehicle accidents, falls and water related accidents. Currently available treatments only offer symptomatic relief but do not target the underlying pathophysiologic changes. The spinal cord injury market is predicted to reach US$3B by 2025. MLP-1236 is a First in class dual inhibitor of matrix metalloproteinases (MMP) 9 and MMP 12 and has already completed Phase 1 and Phase 2a clinical studies. In preclinical models, MLP-1236 was effective in preventing/reversing the neurodegeneration associated with spinal cord injury and ischemic stroke.

MindAffect aims to diagnose visual and hearing impairments in over 2 billion people, including children, seniors, and the disabled, leading to untreated impairments and significant societal costs. Their innovative brain computer interface and AI technology offer a solution by analyzing brain responses to auditory or visual stimuli, reducing testing time and improving accuracy.

Mitracept presents an innovative solution to address the challenges associated with LVOTO during TMVR. Through a groundbreaking, minimally invasive technology developed in partnership with the Mayo Clinic, the device helps reduce the risk of LVOTO during TMVR significantly. This approach provides a level of precision, control, and adaptability suitable for both non-calcified and calcified anatomies. By offering a simple and effective solution that fits in seamlessly with the procedural flow of TMVR, Mitracept reduces procedure time, complexity, and associated risks.

NC Biomatrix offers a solution for treating chronic back pain caused by intervertebral disc degeneration. Current treatments only address symptoms, have limited effectiveness and often come with complications. NC Biomatrix introduces a new approach using a bio-inductive protein extract obtained from porcine notochordal biomatrix. This injectable treatment addresses the underlying pathology and aims to restore the degenerated disc as a way to definitively treat chronic back pain.

With over 50 million people living with Alzheimer's and numbers expected to triple by 2050, there's an urgent need for effective treatments. Alzheimer's is a leading cause of death and imposes a global economic burden of $1 trillion annually. Our novel DYRK1A inhibitor aims to slow or even reverse Alzheimer's progression by targeting key pathways with high specificity and effective blood-brain barrier penetration. This innovative small molecule offers superior disease-modifying potential, addressing current treatment limitations and providing new hope for patients and healthcare systems worldwide.

Neurolieve Biosciences, a pre-clinical stage company, is developing Fc2-13 GalR2, an innovative bioengineered protein (FC fusion protein) targeting neuropathic pain. Peripheral Neuropathy, a debilitating condition affecting millions, damages the peripheral nervous system, causing severe discomfort and lowering quality of life. The fusion protein reduces peripheral neuron excitability, providing pain relief. After successful in vitro and in vivo validations, the company is advancing towards GLP toxicology studies completion.

Nicolab tackles the challenge of stroke diagnosis and treatment by offering computational support through their portfolio of six algorithms. These algorithms analyze radiological images of acute stroke patients, providing fast and objective interpretation for physicians. With stroke affecting millions annually and significant economic burdens, Nicolab's solution improves decision-making speed and accuracy, allowing clinicians to assess stroke severity objectively and make timely treatment decisions.

Nilocas offers a revolutionary solution for detecting coronary artery disease non-invasively and without radiation. Patients wear a lightweight chest patch that captures the sounds of turbulent blood flow through arteries using microphones and accelerometers. Advanced machine learning and AI rapidly analyze the data, providing a clear diagnosis in just 10 minutes. This innovation eliminates the need for costly and invasive procedures, making cardiac diagnosis more accessible in both clinical and non-clinical settings.

OCCLUNOVA introduces a novel solution for chronic atrial fibrillation (AF), a condition affecting millions worldwide where the heart's upper chambers beat irregularly. Their implantable device aims to prevent strokes associated with AF by sealing off the left atrial appendage (LAA), where blood clots often form. Unlike traditional methods, which can cause complications due to their rigid frame, OccluNova's design uses a flexible balloon to fully seal the LAA. This innovative approach minimizes risks like pericardial effusions and incomplete closure, offering a safer option for AF patients.

OSTEOWELD introduces an ultrasonic welding system for bone fractures. Unlike traditional methods with limited fixation options, OSTEOWELD welds polymer-based screws directly to bone or metal implants using high-frequency vibrations. This innovative approach offers more versatility, shorter procedure times, and reduced radiation exposure, making it ideal for complex fractures, especially around joints.

PEP Health addresses the complexity of monitoring healthcare quality by offering a platform that tackles key challenges in quality assessment. By combining multiple sources of patient feedback, including social media, PEP provides near real-time assessments of quality for hospitals and departments. This approach reduces costs, improves timeliness, and enhances trustworthiness compared to traditional methods. With potential customers ranging from healthcare providers to patient organizations, PEP's underlying algorithm has been validated across industries, including higher education.

Pasithea improves treating obstructive sleep apnea (OSA), a condition affecting millions worldwide. Traditional treatments like continuous positive airway pressure (CPAP) face high refusal and dropout rates. Pasithea offers a non-invasive solution based on triggered kinesthetic stimulation. By detecting early signs of apnea or hypopnea and inducing a controlled response, Pasithea activates muscle control centers to prevent oxygen desaturation and associated cardiovascular risks, aiming to improve patient compliance and outcomes.

Persuasive addresses the challenge of identifying Stable Angina patients early on, crucial for preventing heart attacks. Currently, without a diagnostic test in general practitioner settings, many referrals to hospitals prove unnecessary. The solution is a simple blood test, leveraging an extracellular vesicle protein signature to distinguish SA patients from those with non-cardiac chest pain. This innovative approach promises to streamline patient management, saving lives and healthcare resources.

Polynerve is a cutting-edge solution for repairing nerve injuries, offering a better alternative to traditional methods like autografting. Its unique design helps nerves grow in the right direction, reducing complications and surgical time. This absorbable option improves patient recovery and simplifies surgery for healthcare providers, making it a game-changer in nerve repair procedures.

Porous GmbH has developed an ultrasound technology that accurately diagnoses cortical bone health, addressing the limitations of traditional methods. Osteoporosis affects millions globally, leading to frequent and costly fractures. Current diagnostics often miss early-stage bone deterioration, but Porous GmbH’s patented algorithms allow ultrasound to measure bone quality at a microscopic level for a safer and more precise method for early detection of osteoporosis, also reducing healthcare costs.

ProVascTec offers a novel solution for chronic arterial disease, focusing on peripheral arterial disease (PAD) and chronic limb ischemia. Unlike traditional treatments like angioplasty or bypass surgery, ProVascTec aims to stimulate vascular tissue growth using mesenchymal stem cells, reducing complications and improving blood flow. This innovative approach has the potential to benefit millions of patients suffering from PAD worldwide.

NLC's venture, Profionics, advances Cardiff University's sepsis research with a biomarker test combining AI, gene expression, and metabolic analysis for rapid, accurate diagnosis. This test, which works in under 30 minutes with a drop of blood, surpasses traditional methods by quickly identifying those needing antibiotics and reducing unnecessary use, thus combating antimicrobial resistance and saving lives. Particularly impactful in neonatal care, it ensures timely detection critical for newborn survival. Founded by NLC, Cardiff University, and CEO Darren Fergus, Profionics leverages extensive research and a blood sample BioBank, positioning itself as a leader in host response diagnostic testing.

The Pryfiber single multimode optical fiber endoscope, with an ultrathin diameter of less than 300 microns, uses an AI algorithm for real-time calibration to create accurate images. This minimally invasive technology allows for precise diagnostics and treatment in areas like joints, cardiac arteries, and neurosurgery, offering a safer and more effective alternative to traditional, more invasive methods.

Respiosa offers a groundbreaking solution for obstructive sleep apnea (OSA), a condition affecting millions worldwide. Unlike traditional treatments like CPAP or surgery, Respiosa provides a minimally invasive, surgically implanted solution specifically targeting tongue-based obstruction, a common cause of OSA. Developed by Philips, Respiosa promises effective, durable, and adjustable therapy with a quick recovery time. With its natural and unobtrusive design, Respiosa ensures high patient adherence, addressing a significant gap in OSA treatment options.

Retinacheck addresses the challenge of Diabetic Retinopathy, the leading cause of blindness in working-age adults, particularly in regions with poor access to eye care. With over 23% of China's 110 million diabetics affected, Retinacheck's solution becomes crucial. By utilizing retinal images captured by a fundus camera, their Convolutional Neural Network algorithm can diagnose Diabetic Retinopathy with over 94% accuracy, surpassing traditional methods.

Sansepsis is a new treatment for sepsis, a serious condition causing many hospital deaths. Developed by Sanquin, a top blood bank in Europe, it uses a special filtering technology called apheresis to remove harmful pathogens from the blood. This innovative approach aims to improve patient outcomes and reduce the high costs associated with treating sepsis, offering hope for better management of this deadly condition.

Scinvivo introduces a solution for bladder cancer diagnosis with its imaging catheter, providing real-time, cross-sectional tissue images. Traditional methods often lead to unnecessary surgeries and missed tumors. By utilizing Optical Coherence Tomography technology, Scinvivo's catheter offers high-resolution imaging, enabling urologists to accurately diagnose bladder conditions. This approach reduces unnecessary surgeries but also enhances diagnostic accuracy, improving patient outcomes.

SelfSafeSure's Blood Collection Assist Device (BCAD) revolutionizes at-home blood collection, offering a clean and reliable solution compatible with standard hospital analyzers. Developed by the Netherlands Cancer Institute, this device is ideal for monitoring conditions like infectious diseases, prostate cancer, and diabetes, SelfSafeSure's BCAD enhances early intervention and compliance while alleviating the burden on diagnostic centers.

SERDA presents a solution for wound debridement, particularly useful for burn wounds and chronic wounds like diabetic foot ulcers. Traditional debridement methods can be expensive, painful, or less effective. SERDA offers an enzymatic debrider in the form of a hydrogel that selectively breaks down necrotic tissue, leaving healthy tissue intact, promoting faster healing with minimal discomfort for the patient. SERDA aims to improve the efficiency and ease of wound care, providing a more effective alternative to existing options.

StarTric, created by cardiovascular experts, developed a new, less invasive device to fix a serious heart valve problem, Tricuspid Regurgitation (TR). Addressing Tricuspid Regurgitation (TR), a severe condition with high mortality rates, StarTric's device offers a safer alternative to open-heart surgery. The technology can be implanted via a transfemoral catheter, combining the safety of minimally invasive methods with the proven efficacy of the Clover technique, aiming to provide effective treatment to millions of TR patients worldwide who currently lack suitable options.

TherageniX introduces an approach to improve bone implants by augmenting autologous bone grafts with regenerative gene therapies. Traditional bone repair methods face challenges like rejection, infection, and limited regenerative capacity. TherageniX's solution aims to enhance the regenerative bone grafts, improving functional outcomes and reducing donor trauma. This method bypasses regulatory and manufacturing hurdles, offering a promising advancement in bone grafting procedures.

Timelab addresses the challenge of ambulance delays in the Netherlands by offering a proactive solution through their Emergency Mathematics software. With 7% of ambulance arrivals exceeding the 15-minute target, 35,000 patients annually don't receive timely care, impacting mortality and morbidity rates. Timelab's software predicts future demand and facilitates the proactive relocation of ambulances, aiming to reach 95% of high emergency call locations within 15 minutes, compared to the current 93%.

The Venous Stent is a new type of stent designed to help with conditions like deep vein thrombosis (DVT) and post-thrombotic syndrome (PTS). Unlike older stents, this one can adjust in length and has multiple parts, making it more flexible and better for the veins. It helps improve blood flow and healing in the veins, potentially reducing the need for long-term medication.

Wavefront is revolutionizing live-cell imaging with their AI-driven computational microscope, offering a stain-free imaging technique powered by patented quantitative-phase-imaging (QPI) technology. This approach eliminates the need for costly and invasive chemical staining, preserving cell integrity with real-time visualization of cellular structures with precision and detail. Wavefront's innovative solution has transformative potential research across diverse fields, from cancer research to clinical diagnostics.

XtRNA Bio is developing a pioneering gene therapy to treat Charcot Marie Tooth (CMT) disease type 2D, leveraging tRNA supplementation therapies. Their patented treatment targets mutations in tRNA synthetases, offering a new therapeutic modality with vast potential for various diseases. They are raising €5M to develop a clinical candidate for CMT2D and expand their pipeline. CMT, a hereditary and heterogeneous disease, affects 1 in 2500 people worldwide, causing progressive muscle wasting, loss of sensation, and chronic pain, with no current cure.